Alteration of Cytokine Profiles in Uranium Miners Exposed to Long-Term Low Dose Ionizing Radiation

OBJECTIVE The aim of the study is to estimate the immune function through cytokine profiles in sera of uranium mines. METHODS Antibody arrays were used to detect 50 cytokines in sera of uranium miners. Miners who had continuously worked underground for <5 years were treated as control group and those who worked for ⩾ 5 years as experimental group. RESULTS Of 28 measurable cytokines, the release of IL-1 α , IL-1RI, IL-15, IL-3, and IP-10 were significantly upregulated in the experimental group, and no cytokine was found significantly downregulated. Other proinflammatory cytokines such as IFN-γ, IL-10, IL-6, and TNF α levels were slightly upregulated in the experimental group. With adjustment to age, BMI, and cigarette smoking, IL-1 α and IL-3 levels increased significantly with underground time. CONCLUSION Alteration of cytokine profiles in this study may indicate persistent inflammatory responses in uranium miners exposed to long-term low doses radiation.